Cleaning validation using the Sievers TOC meter.
The use of TOC in cleaning validation is gaining attention.
TOC is an effective tool for cleaning validation of pharmaceuticals, cosmetics, and medical devices. By using TOC for cleaning validation, it is possible to achieve quality improvement, risk reduction, and efficient operations. TOC is a simple analytical method that quickly detects low concentrations of organic compounds and can identify degradation products and contaminants that HPLC cannot detect. Compared to HPLC, which is a specific analytical method that detects only specific components, TOC, being a non-specific analytical method, can comprehensively confirm that excipients, degradation products, and cleaning agents are adequately cleaned. Furthermore, TOC simplifies method development and has less equipment downtime, leading to increased efficiency. By using TOC, not only can the cleaning process be evaluated quickly, but it also reduces workload, maintenance costs, and running costs compared to HPLC.
- 企業：セントラル科学
- 価格：Other
